SRIDHAR HANNENHALLI,
Ph.D.
1986-90 B.Tech. Institute of
Technolgy, Varanasi, India (Computer Science)
1990-92 M.S. University of Central
Florida, Orlando, FL (Computer Science)
1992-95 Ph.D. Pennsylvania State University,
University Park, PA (Computer Science with Dr. Pavel Pevzner)
1996-97 Postdoc. Res. Fellowship, Dept. of Math,
University of Southern California, Los Angeles, CA
Appointments
Sep 15, 2003 - Present Asst.
Professor, Dept. of Genetics, University of Pennsylvania
Sep 2000 - Aug 2003 Prinicipal Bioinformatics
Scientist, Celera Genomics
July 1997 - Aug 2000 Senior computational
biologist, SmithKline Beecham Pharma
Scientific Committees
2007 Workshop on Algorithms in Bioinformatics (program co-chair)
2004-2006 RECOMB Satellite
conference on Transcriptional Regulation program
committee
2006-present
Asia Pacific Bioinformatics Conference (APBC) program
committee
2001-2006 RECOMB program
committee
2002 RECOMB Organizing Chair
Research Publications (peer reviewed)
-
K. Hua and S. Hannenhalli:
Parallel transitive closure computations using topological sort.
Proc. of Intl. conf. on Parallel and Distributed Information Systems,
(1991).
-
S. Hannenhalli and K. Perumalla and N. Chandrasekharan and R.
Sridhar:
A distributed algorithm for ear decomposition.
Proc. of Intl. conf. on
Computing and Information,
(1993): 180-184.
-
N. Chandrasekharan and S. Hannenhalli:
Efficient algorithms for computing matching
and chromatic polynomials in series-parallel graphs.
Journal of Combinatorial Mathematics and Combinatorial Computing,
1994(15): 19-32.
-
M. Borah and S. Hannenhalli and R. Bajwa and M. Irwin
A SIMD solution to the
sequence comparison problem on the MGAP.
Proc. of Intl. conf. on
Application Specific Array Processing,
(1994): 336-345.
-
S. Hannenhalli and P. Pevzner:
Transforming men into mice (polynomial algorithm for genomic distance
problem).
36th Annual IEEE Symposium on Foundations of Computer Science,
(1995):581-592.
-
S. Hannenhalli and P. Pevzner:
Transforming cabbage into turnip (polynomial algorithm for sorting
signed permutations by reversals).
Proc. 27th Annual ACM Symposium on the Theory
of Computing,
(1995):178-189.
-
S. Hannenhalli and C. Chappey and E. Koonin and P. Pevzner:
Genome sequence comparison
and scenarios for gene rearrangements: A test case.
Genomics,
1995(30): 299-311.
-
S. Hannenhalli and P. Pevzner and H. Lewis and S. Skeina and W.
Feldman:
Positional sequencing by hybridization.
CABIOS,
1996(12): 19-24.
-
P. Berman and S. Hannenhalli:
Fast sorting by reversal.
Combinatorial Pattern Matching,
(1996): 168-185.
-
S. Hannenhalli:
Polynomial algorithm for computing translocation distance between
genomes.
Journal of Discrete Applied Math (Special Issue on Computational
Molecular Biology)
71(1996): 137-152
-
S. Hannenhalli and P. Pevzner:
To cut ... or not to cut (applications of comparative physical maps in molecular
evolution).
Seventh Annual ACM-SIAM Symposium on Discrete Algorithms,
(1996):304-313.
-
R. Agarwala and S. Batzoglou and V. Dancik and S. Decatur and S.
Hannenhalli and M. Farach and S. Muthukrishnan and S. Skiena:
Local rules for protein folding on
a triangular Lattice and generalized hydrophobicity in HP model.
Journal of Computational Biology,
4(1997):275-296.
-
V. Dancik and S. Hannenhalli and S. Muthukrishnan:
Hardness of flip-cut problems from
optical mapping.
Journal of Computational Biology,
4(1997):119-125.
-
S. Hannenhalli and W. Hayes and A. Hatzigeorgiou and J. Fickett:
Bacterial start site prediction.
NAR,
27(1999):3577-3582.
-
V. Bafna and S. Hannenhalli and K. Rice and L. Vawter:
Ligand-receptor pairing via
tree comparison.
Journal of Computational Biology, 7(2000):59-70.
-
S. Hannenhalli and R. Russell:
Analysis and prediction of protein functional sub-types from protein
sequence alignments.
Journal of Molecular Biology, 202(2000):61-76.
-
J.C.
Venter et al.:
The human genome.
Science, 291
(2001):1304-1351.
-
S. Hannenhalli and S. Levy:
Promoter prediction in human genome.
ISMB 2001, Bioinformatics, 17
(2001):S90-S96.
-
S. Levy and S. Hannenhalli and C. Workman:
Enrichment of regulatory signals
in conserved non-coding genomic sequence.
ISB 2001, Bioinformatics, 1
(2001):1-7.
-
P. Berman and S. Hannenhalli and M. Karpinski:
1.375-Approximation algorithm for
sorting by reversals.
ESA
(2002)
-
S. Levy and S. Hannenhalli:
Identification of transcription factor binding sites in the human
genome.
Mammalian Genome, 13(2002):510-514.
-
S. Hannenhalli and S. Levy:
Predicting transcription factor synergism.
Nucleic Acids Research, 2002 30:
4278-4284.
-
S. Hannenhalli and S. Levy:
Transcriptional regulation of protein complexes and pathways.
Mammalian Genome, 14(2003):611-619
-
S. Istrail et al.:
Whole-genome shotgun assembly and comparison of human genome
assemblies.
PNAS USA,2004 101(7): 1916-21
-
V. Bafna and D. Gusfield and S. Hannenhalli and S. Yooseph:
A Note on Efficient Computation of Haplotypes via Perfect Phylogeny,
Journal of Computational Biology, 2004 11(5): 858-866
-
M. K. Lewinski, D. Bisgrove, P. Shinn, H. Chen, S. Hannenhalli, E.
Verdin, C. C. Berry, J. R. Ecker, and F. D. Bushman:
Genome-wide
analysis of chromosomal feature repressing HIV transcription.
J. Virology, 2005 79(11): 6610-6619.
-
S. Hannenhalli and L.S. Wang:
Enhanced position weight matrices using mixture models.
Bioinformatics,
2005 Vol 21(Suppl 1):i204-212
-
L.S. Wang, S.T. Jensen, S. Hannenhalli: An
Interaction-dependent model for transcription factor binding
(2005)
RECOMB-Regulation,
To appear in
Lecture Notes in Computer Science.
-
J. Wang
and S. Hannenhalli: Generalized Markov models for sequence
classification. BMC Bioinformatics, 2005 6:219
-
M.B. Keeley, M. Wood, C. Isiegas, J. Stein, K. Hellman, S.
Hannenhalli, T. Abel:
Differential Transcriptional Response to Non-Associative and
Associative Components of Classical Fear Conditioning in the Amygdala
and Hippocampus
Memory and Learning,
2006,
13,
135-142.
-
D. A. Ross, S.
Hannenhalli, J. Tobias, N. Cooch, R. Shiekhattar and T. Kadesch:
Functional
analysis of Hes-1 in preadipocyte.
Mol Endocrinol, 2006,
20:698-705.
-
Lewinski, M.
K., Yamashita, H., Emerman, M., Shinn, P., Leipzig, J., Hannenhalli,
S., Berry, C., Ecker, J. R., Bushman, F.D.:
(2006).
Retroviral gag and integrase act synergistically to determine integration target
specificity. PLoS Pathogens, 2006, 2(6):e60
-
L.
Everett , L.S. Wang, and S. Hannenhalli: Dense subgraph
computation via stochastic search: application to detect
transcriptional modules.Bioinformatics, 2006, 22(14):e117:23
- S. Hannenhalli, R. P.
Middleton, S. Levy, B. Perroud, J. A. Holzwarth, K. McDonald, and S.
S. Hannah: Identification and Cross-Species Comparison of Canine
Osteoarthritic Gene Regulatory cis-Elements.
OSTEOARTHRITIS AND CARTILAGE,
2006, 14(8): 830:8
- J.
Wang and S. Hannenhalli: A mammalian promoter model links cis
elements to genetic networks. Biochem Biophys Res Commun, 2006,
347(1):166-177
-
P. Evans, G. Donahue and
S. Hannenhalli: Conservation patterns in cis-elements reveal
compensatory mutations ,RECOMB-Comparative Genomics,
Lecture Notes in Computer Science, 2006,4205:186-199
-
H. Hinsch and S.
Hannenhalli: Recurring genomic breaks in independent
lineages support genomic fragility,BMC
Evolutionary Biology, 2006,6:90
-
S. Hannenhalli, M. Putt,
J. Gilmore, J. Wang, M. Parmacek, J. Epstein, E. Morrisey, K.
Margulies and T. Cappola: Transcriptional genomics associates
FOX transcription factors with human heart failure. Circulation,
2006, 114(12):1269-76
- D. Hadley, T. Murphy, O. Valladares, S.
Hannenhalli, L. Ungar, J. Kim, M. Bucan:
Patterns of Sequence Conservation in Presynaptic Neural Genes.
Genome Biology, 2006, 7(11):R105
- C. Berry, S. Hannenhalli,
J. Leipzig and F. Bushman:
Selection of Target Sites for Mobile DNA Integration in the Human
Genome,
PLoS Comput
Biol, 2006, 2(11):e157
- Y. Zhang, N. Rath, S. Hannenhalli, Z. Wang,
T. Cappola, S. Kimura, E. Atochina-Vasserman, M.M. Lu, M. Beers, and
E.E. Morrisey:
GATA and Nkx factors synergistically regulate tissue specific gene
expression and development in vivo.
Development, 2007, 134(1):189-98
- N. Minkah, Y. Hwang, K. Perry, G.D. Van
Duyne, R.C. Hendrick, E.J. Lefkowitz, S. Hannenhalli, F. Bushman::
Variola Virus Topoisomerase: DNA Cleavage Specificity and
Distribution of Sites in Poxvirus Genomes.
Virology, 2007,365(1):60-69
-
S.
Vardhanabhuti, J. Wang, S. Hannenhalli:Position
and distance specificity are important determinants of cis-regulatory
motifs in addition to evolutionary conservation.
NAR, 2007,35(10):3203-13
-
Y. Zhang, N. Rath,
S. Hannenhalli, Z. Wang, T. Cappola, S. Kimura, E. Atochina-Vasserman,
M.M. Lu, M. Beers, and E.E. Morrisey:GATA
and Nkx factors synergistically regulate tissue specific gene
expression and development in vivo.
Development, 2007,134(1):189-98
-
J.
Wang, S. Hannenhalli, L. Ungar:MetaProm:
a neural network based meta-predictor for alternative human promoter
prediction. BMC
Genomics, 2007,374(8):374-386
-
L.N. Singh, L.S.
Wang, S. Hannenhalli:TREMOR
– A tool for retrieving transcriptional modules by incorporating
motif covariance.
NAR, 2007,35(21):7360-71
-
S. Yang, K. Wang,
O. Valladares, S. Hannenhalli and M. Bucan:Genome-wide
expression profiling and bioinformatics analysis of diurnally
regulated genes in the mouse prefrontal cortex.
Genome Biology, 2007,8(11):R247
- L. Singh and S. Hannenhalli:Functional
diversification of paralogous transcription factors via divergence in
DNA binding site motif and in expression.
PLoS ONE, 2008,((in press)
Editorials, Reviews, Chapters
- S. Hannenhalli and P. Pevzner:
Towards a computational theory of genome rearrangements. Lecture Notes
in Computer Science,1995, 1000:184-202.
- S. Hannenhalli, E. Hubbell, R. Lipshutz and P.
Pevzner: Combinatorial Anlysis for design of DNA Arrays. Chip Technology
(editor J. Hoheisel), Springer-Verlag, 2002:1-19.
- F.
Bushman, M. Lewinski, A. Ciuffi, S. Barr, J. Leipzig, S. Hannenhalli, C.
Hoffmann:
Genome-wide analysis of retroviral DNA integration. Nat Rev Microbiol,
2005, 3(11):848-58
Invited Lectures/ Workshops (last 5 years)
-
Nov 2003. Transcritional Regulation: Signals, Interactions and Modules at Penn
State University, State College, PA
-
Feb 2004.
Computational analysis of transcriptional regulation, at Villanova
University, Villanova, PA
-
Nov 2004.
Computational analysis of transcriptional regulation, at CHOP, PA
-
Dec 2005.
Transcription regulation analysis: theory and applicaiton, at Thomas
Jefferson University, PA
-
Jun 2006. Transcription factor DNA binding specifcity (or lack thereof),
Bertinoro Bioinformatics Meeting, Bertinoro, Italy.
- Aug 2006. Deciphering Gene
Regulatory Networks by in silico approaches, BIOKDD international
conference, Philadelphia, PA
- Oct 2006. Deciphering Gene
Regulatory Networks by in silico approaches, George Washington
University, Washington D.C
- Nov 2006. Deciphering Gene
Regulatory Networks by in silico approaches, Brown University,
Providence
- Jul 2007.
Signals, interactions and Networks, Center for Gene Regulation,
Barcelona, Spain
- Aug 2007.
Computational Analysis of Transcriptional Regulation, Emerging
Information and Technology Conference, Princeton University, Princeton.
- Oct 2007.
In silico approaches to transcriptional regulation and evolution. NHGRI,
NIH, Bethesda, MD. Nov 2007. In silico approaches to
transcriptional regulation and its evolution, Princeton, NJ .
- Feb 2008.
Computational analysis of eukaryotic transcriptional regulation and its
evolution, Center for comp bio and bioinformatics, Indiana University
Purdue University, Indianapolis.
- Mar 2008.
Computational analysis of eukaryotic transcriptional regulation and its
evolution, Carnegie Mellon University, Pittsburgh.
- Apr 2008.
Computational analysis of eukaryotic transcriptional regulation and its
evolution, J Craig Venter Institute, Rockville.
Patents
1. S. Hannenhalli and Robert Russell, Analysis
and prediction of protein functional sub-types from protein sequence alignments,
European Patent # EP1096411